Bridged Nucleic Acids Reloaded

Third Generation Super Functional Bridged Nucleic Acids: BNA3TM

Nucleic Acids

The first isolation of what we now refer to as DNA was accomplished by Johann Friedrich Miescher circa 1870. He reported finding a weakly acidic substance of unknown function in the nuclei of human white blood cells, and named this material "nuclein". A few years later, Miescher separated nuclein into protein and nucleic acid components. In the 1920's nucleic acids were found to be major compon...

Nucleic acids.

In: Dyer A, Hudson HG and Williams PA (eds) Ion Exchange Processes: Advances and Applications, p. 39. Cambridge, UK: The Royal Society of Chemistry. Lehto J and Harjula R (1997) Selective separation of radionuclides from nuclear waste solutions with inorganic ion exchangers, React Funct Polym (in press). Navratil JD (1989) Ion exchange technology in spent fuel reprocessing. Journal of Nuclear S...

[Nucleic acids].

E wish to suggest a structure for the salt of deoxyribose nucleic acid (D.N.A.). This structure has novel features which are of considerable biological interest. A structure for nucleic acid has already been proposed by Pauling and Corey. They kindly made their manuscript available to us in advance of publication. Their model consists of three intertwined chains, with the phosphates near the fi...

2'-O,4'-C-ethylene-bridged nucleic acids (ENA) as next-generation antisense and antigene agents.

Novel 2'-O,4'-C-ethylene nucleosides have been synthesized as building blocks for antisense and antigene oligonucleotides. 2'-O,4'-C-Ethylene-bridged nucleic acids (ENA) comprising 2'-O,4'-C-ethylene nucleosides have considerable affinity to complementary RNA and double-stranded DNA. Incorporation of 2'-O,4'-C-ethylene nucleosides into oligonucleotides dramatically increase their resistance aga...